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Irinotecan (Camptosar)

Irinotecan: Interactions With Other Drugs And Food

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© American Cancer Society 2010

Interactions with other drugs

Irinotecan can interact with a number of drugs and supplements, which may either raise or lower the level of irinotecan in your blood. Tell your doctor if you are taking any of the following:

  • anti-depressant drugs nefazodone (Serzone), fluvoxamine (Luvox), fluoxetine (Prozac, Serafem)
  • antibiotics erythromycin, clarithromycin, and similar drugs
  • anti-fungal antibiotics such as ketoconazole and itraconazole
  • the anti-nausea drug aprepitant
  • certain blood pressure medicines such as diltiazem and verapamil
  • HIV drugs such as indinavir, ritonavir, amprenavir, fosamprenavir, nelfinavir, atazanavir, and others
  • anti-seizure drugs carbamazepine, phenobarbital, and phenytoin can make the body get rid of irinotecan faster
  • TB drugs rifampin and rifabutin
  • St. John's wort (an herbal dietary supplement)

Don't start or stop taking any drugs while you are on irinotecan without talking with your doctor first.

This drug can cause serious diarrhea. Try to avoid laxatives and stool softeners while taking this drug.

There may be more drugs that interact with irinotecan. Check with your doctor, nurse, or pharmacist about your other medicines, herbs, and supplements, and whether alcohol can cause problems with this medicine.

Interactions with foods

Grapefruit or grapefruit juice may also change the level of this drug in your blood. Check with your doctor, nurse, or pharmacist about whether these or other foods may be a problem.

Tell all the doctors, dentists, nurses, and pharmacists you visit that you are taking this drug.

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