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The Different Types of Chemotherapy Drugs

Mitotic Inhibitors

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© American Cancer Society 2010

Mitotic inhibitors are often plant alkaloids and other compounds derived from natural products. They can stop mitosis or inhibit enzymes from making proteins needed for cell reproduction. These work during the M phase of the cell cycle but can damage cells in all phases. They are used to treat many different types of cancer including breast, lung, myelomas, lymphomas, and leukemias. These drugs are known for their potential to cause peripheral nerve damage, which can be a dose-limiting side effect.

Examples of mitotic inhibitors include:

  • the taxanes: paclitaxel (Taxol ®), docetaxel (Taxotere ®)
  • epothilones: ixabepilone (Ixempra ®)
  • the vinca alkaloids: vinblastine (Velban ®), vincristine (Oncovin ®), and vinorelbine (Navelbine ®)
  • estramustine (Emcyt ®)

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